![]() A ternary phase diagram has the shape of a triangular prism with an equilateral triangle as a foundation which is used to describe a three component system. A phase diagram is a graphical representation composed of area curve, lines and points, which is used to describe a specific system composed of a single or multiple components and generate the data with respect to concentration of different components, temperature and pressure at which thermodynamically distinct phases occur, transform from one phase to another and coexist at equilibrium. Phase diagram serves as an important tool for screening of such formulation components. Various pharmaceutical formulations such as emulsion, micro emulsions and gels are mainly composed of lipid soluble component, water soluble component, surfactant and cosolvents. The phase rule given by J.W Gibbs in 1874 is applied to define a system composed of single component as well as multi-component. A phase is a physically discrete and chemically homogeneous portion of a system, separated by boundaries from other portions of the system.
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